Detalhe da pesquisa
1.
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease: Opportunities for therapy.
Alzheimers Dement
; 20(2): 1421-1435, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37897797
2.
Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers.
Alzheimers Dement
; 19(2): 671-695, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36401868
3.
FDA-approved carbonic anhydrase inhibitors reduce amyloid ß pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness.
Alzheimers Dement
; 19(11): 5048-5073, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37186121
4.
A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease.
Int J Mol Sci
; 20(19)2019 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31554165
5.
The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain.
Neurobiol Dis
; 86: 29-40, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26581638
6.
Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration.
Biochim Biophys Acta
; 1842(12 Pt A): 2457-67, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25261792
7.
Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid ß and the Asn23 Iowa mutation.
Biochem J
; 456(3): 347-60, 2013 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24028142
8.
Homocysteine potentiates amyloid ß $$ \upbeta $$ -induced death receptor 4- and 5-mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment.
Aging Cell
; : e14106, 2024 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38358083
9.
Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease.
Front Physiol
; 14: 1060666, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36798942
10.
The Effects of Amyloid-ß on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells.
J Alzheimers Dis
; 93(1): 307-319, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36970904
11.
Amyloid ß induces cardiac dysfunction and neuro-signaling impairment in the heart of an Alzheimer's disease model.
bioRxiv
; 2023 Jul 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37502936
12.
Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors.
Cells
; 12(24)2023 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38132159
13.
Screening for PTSD and TBI in Veterans using Routine Clinical Laboratory Blood Tests.
Transl Psychiatry
; 13(1): 64, 2023 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36810280
14.
Insights into caspase-mediated apoptotic pathways induced by amyloid-ß in cerebral microvascular endothelial cells.
Neurodegener Dis
; 10(1-4): 324-8, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22156599
15.
Beta-Amyloid Instigates Dysfunction of Mitochondria in Cardiac Cells.
Cells
; 11(3)2022 01 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35159183
16.
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells.
J Biol Chem
; 285(35): 27144-27158, 2010 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-20576603
17.
Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease.
Cells
; 10(11)2021 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34831125
18.
Analysis of Mitochondrial Calcium Retention Capacity in Cultured Cells: Permeabilized Cells Versus Isolated Mitochondria.
Front Physiol
; 12: 773839, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34950052
19.
Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer's Disease and Stroke.
Front Aging Neurosci
; 13: 772278, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34867298
20.
CRF serum levels differentiate PTSD from healthy controls and TBI in military veterans.
Psychiatr Res Clin Pract
; 3(4): 153-162, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-35211666